Rose Wylie makes large-scale paintings inspired by a wide range of visual culture. Her subject matter ranges from contemporary Egyptian Hajj wall paintings and Persian miniatures to films, news stories, celebrity gossip, locker room, sweet hearts, townie bimboes, billboards, alongside faces, dots in dresses, and her observation of daily life.

Wylie produces bold and loosely-painted canvases that are often made up of multiple panels. Her compositions and repeated motifs are informed by the cut-out techniques of collage and the framing devices of film, cartoon strips and Renaissance predella panels. Often working from memory, she distils her subjects into succinct observations, using text to give additional emphasis to her recollections